Journal article
Antibodies that induce phagocytosis of malaria infected erythrocytes: Effect of HIV infection and correlation with clinical outcomes
R Ataíde, V Mwapasa, ME Molyneux, SR Meshnick, SJ Rogerson
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011
Abstract
HIV infection increases the burden of disease of malaria in pregnancy, in part by impairing the development of immunity. We measured total IgG and phagocytic antibodies against variant surface antigens of placental-type CS2 parasites in 187 secundigravidae (65% HIV infected). In women with placental malaria infection, phagocytic antibodies to CS2 VSA were decreased in the presence of HIV (p = 0.011) and correlated positively with infant birth weight (coef = 3.57, p = 0.025), whereas total IgG to CS2 VSA did not. Phagocytic antibodies to CS2 VSA are valuable tools to study acquired immunity to malaria in the context of HIV co-infection. Secundigravidae may be an informative group for identifi..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
RA is supported by Fundacao para a Ciencia e Tecnologia, Portugal, reference SFRH/BD/32985/2006. Patient recruitment was supported by a grant from National Institutes of Health (NIH) to SRM (NIH RO1 award number AI 49084). SJR is supported by the National Health and Medical Research Council, Australia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.